Pathogenesis of Cardiac Sarcoidosis According to an Etiologic Hypothesis as Caused by Propionibacterium Acnes

Etiologic Aspect of Sarcoidosis as an Allergic Endogenous Infection Caused by Propionibacterium acnes

Sarcoidosis is a systemic granulomatous disease of unknown etiology. Propionibacterium acnes is the only microorganism that has been isolated from sarcoid lesions. Many P. acnes have been detected in sarcoid lymph nodes using quantitative PCR and in sarcoid granulomas by in situ hybridization. P. acnes trigger factor protein causes a cellular immune response only in sarcoid patients and induces...

Propionibacterium acnes as a Cause of Sarcoidosis

Recurrent Epidural Abscess Caused by Propionibacterium Acnes

Introduction Epidural abscess is a suppurative fluid collection in the epidural space that, if not treated promptly, may result in severe consequences. It is caused most commonly by Staphylococcus aureus followed by Gram negative bacilli, streptococcus species, and coagulase negative staphylococci. 1,2 A rare case of recurrent epidural abscess caused by an unusual pathogen, Propionibacterium ac...

Splenic abscess caused by Propionibacterium acnes.

A 59-year-old male diabetic was admitted with an acute myocardial infarction and had recurrent. Propionibacterium acnes bacteremia. Fifteen months after the initial admission a splenectomy was required for removal of a large splenic abscess caused by P. acnes. Although this organism represents part of the normal skin flora, its presence of blood cultures requires serious evaluation since it may...

Alveolar lymphocyte proliferation induced by Propionibacterium acnes in sarcoidosis patients.

The proliferation of lymphocytes induced by Propionibacterium acnes (P. acnes) was measured by the in vitro incorporation of 3H-thymidine. The mean response rate of alveolar lymphocytes obtained by bronchoalveolar lavage was 2.23 +/- 0.89 in nine untreated sarcoidosis patients, 0.85 +/- 0.17 in five sarcoidosis patients given corticosteroids and 0.78 +/- 0.29 in 11 controls. The proliferation w...